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Synthol is used in small groups of muscles to enlarge their volume (for example triceps, biceps, deltoids, A review of several studies found that synthol use may lead to life-long health complications. Synthol can also leave muscles misshapen and out of proportion to other muscles in the body. What’s more, researchTrusted Source shows that synthol may also cause muscle fibrosis. This painful and potentially irreversible condition causes muscle tissue to become so scarred that it may die and have to be removed surgically. Synthol can also lead to some serious, potentially life-threatening complications — especially if the compound is injected directly into a vein or artery, or if the syringe injures a nerve during the injection.